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The analgesic and anti-inflammatory properties acts by inhibiting two recognized isoenzymes of prostaglandin G/H synthase also known as cycl-oxygenase (COX), which are COX 1 and COX 2.The pharmacodynamic action of these drugs is mostly mediated by inhibition of COX2, while the adverse reactions are largely due to COX1 inhibition

Delayed administration of neural stem cells after hypoxia-ischemia reduces sensorimotor deficits, cerebral lesion size, and neuroinflammation in neonatal mice

Paulose et al., 2013)

Although the underlying mechanisms for esophageal hypersensitivity remain unclear, RH patients typically experience more frequently weakly acidic reflux events, heightened sensitivity compared to those with FH, and a greater incidence of proximal reflux, factors that may contribute to their symptoms

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