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The mechanism of decreased lipid turnover with aging may be due to decreased sympathetic tone (236)

Quality varies significantly between sources, and independent testing for purity and potency is not consistently available

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However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)