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Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the TRIUMPH registrational clinical trials (Diabetes, Obesity & Metabolism)

Ferroptosis, in turn, exacerbates inflammation by releasing oxidized byproducts and iron ions, thereby establishing a detrimental feedback loop involving immunity, metabolism, and ferroptosis within the OA microenvironment (105)

doi:10.1152/physiologyonline.2000.15.6.284

Key Takeaway: Combining NAC and glutathione allows for both immediate antioxidant support and long-term internal production, helping the body manage oxidative stress more effectively than using one alone

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