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Conclusion We identified plasma hypoxanthine as a biomarker for hypoxic ischemic brain injury in an ovine model

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333 Therefore, integrating microbiota management (including dietary guidance, probiotics/prebiotics, selective intestinal decontamination) into the full-course treatment of liver fibrosis/cirrhosis is expected to synergize with existing therapies from multiple dimensions such as reducing pathogenic signal output, enhancing the gut barrier, and regulating immunity, delaying disease progression and improving patient quality of life