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References Heffernan M, et al

Integration of local IGF-I/IGF-IR signaling with systemic hormones Integration with GH Although it is well established that GH stimulates hepatic gene expression to make and supply IGF-I to the circulation, recent studies suggest that changes in circulating IGF-I levels may be an indicator of GH status, but may not be directly involved in controlling local functions in non-hepatic tissues, including bone (68)

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In contrast, foods rich in dietary fiber increase the diversity of the gut microbiota and the production of metabolites, including SCFAs, which have anti-inflammatory effects (160, 161)