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Therefore, the present systematic review, meta-analysis, and dose-response analysis of the existing literature in the form of randomised controlled trials (RCTs) were designed to conclusively answer the question of whether green tea supplementation/consumption could ameliorate the oxidative/inflammatory environment (indicated by clinically relevant factors, including C-reactive protein (CRP), IL-6, IL-1, TNF-, total antioxidant capacity (TAC), malondialdehyde (MDA), GPX, and SOD)

Countless studies show oxidative stress in neurons is a marker of an unhealthy brain

No GHK-Cus mechanism targets tissue remodeling through fibroblast activation and matrix metalloproteinase regulation, which requires localized tissue concentration, not systemic plasma levels

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J Clin Invest 123:236246