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Although tachyphylaxis to this effect may occur with long-acting GLP-1 receptor agonists, GLP-1-associated slowing of gastric emptying does not appear to be responsible for the nausea and vomiting often reported with the use of GLP-1 receptor agonist treatment

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[28] In addition, choline inhibited obesity-induced oxidative stress and prevented hepatic accumulation of triglycerides