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Partly due to this realization, more and more research over the past few years has focused on finding ways to lengthen the average healthspan.2 Besides the positive impacts of lifestyle modifications, like eating right and exercising, some experts are investigating pharmacological or supplemental avenues

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For instance, human microvascular ECs (MVECs) were incubated with Ang II (200 nM) during 48 h, showing ECD and vascular remodeling via downregulation of the ion channel TRPV4/eNOS pathway [95]

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