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Nicotine profoundly disrupts the sleep-wake cycle by altering the activity of neurotransmitters such as acetylcholine, dopamine, and norepinephrine, which regulate arousal and the brain's reward systems

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average, the comparison is even more stark: Tobacco Nation residents heart disease mortality is 25 percent higher than that of the remaining 38 states Co-occurrences and Co-morbidities Compounding the poor tobacco-related health outcomes are the co-occurrences and co-morbidities that often accompany tobacco use