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Nor-epinephrine, a major catecholamine that promotes adipocyte lipolysis (83, 84), is released in response to cold stimulation from terminal neurons that innervate fat cells (83) to mediate non-shivering thermogenesis (85-87) through the activation of -adrenergic receptors (-ARs)

Hydroxocobalamin is the preferred formulation in the UK and carries a lower risk profile, though it may cause a harmless reddish discolouration of urine