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For example, PER1 gene activity, which is often reduced in tumor progression, has been examined as a possible pathway of interest

So, it may be hypothesized, that variability of clinical symptoms of WD, related to the occurrence of hepatic/neurological symptoms at different ages, may be related not only to the modifying influence of genetic and environmental factors, but also to immunological factors responsible for triggering the inflammatory process contributing to liver/CNS damage [198,199]

J Clin Oncol 20(21):43194323 Rajkumar SV et al (2010) Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial

Gaining insight into the underlying mechanisms of ferroptosis and the associated dermatological disorders could illuminate the pathogenesis and treatments of different cutaneous diseases

The choline metabolite, betaine, can also provide a methyl group for the conversion of homocysteine to methionine