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To examine the nitric oxide-dependency in this system, the rings were pretreated with 0.03 mM L-NAME, an eNOS inhibitor or 10 M hemoglobin, a nitric oxide scavenger

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This mechanism is relevant to neuropathy because NF-kB-driven inflammation is a central mediator of nerve damage in diabetic neuropathy, autoimmune neuropathies, and chemotherapy-induced peripheral neuropathy