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It acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme expressed in multiple tissues including adipose tissue and the liver that plays a role in cellular energy metabolism and fat storage

The compound is most often taken with meals, as this may improve absorption and reduce the likelihood of gastrointestinal discomfort

And it explains why some patients who respond poorly to liraglutide see better results when switching to semaglutide, despite both drugs targeting the exact same receptor