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| | 5-Amino-1MQ Monotherapy | None | 50100mg daily | Daily oral or subcutaneous | NNMT inhibition preserves NAD+, activates AMPK and mitochondrial fat oxidation | 812 weeks | Promising preclinical data

On a molecular level, AOD-9604 is compact enough to achieve good solubility in aqueous diluents yet large enough to retain the structural motif needed for its adipocyte-targeting activity

Daily doses are necessary, yet we have many readers who complain of only being able to obtain an injection every few weeks or months

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Oral doses used in animal studies are typically three to ten times higher than equivalent injectable doses to produce comparable systemic effects suggesting oral bioavailability in the range of 1030% relative to parenteral delivery.3 That does not mean oral BPC-157 is ineffective