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As a result, the skin develops signs of dullness, pigmentation, tanning, and uneven tone

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That sequencing is not arbitrary

The mean estimated FVC% was 97.0 at baseline, 72.7 at month 12 and 48.4 at month 24 in treated subjects, with a mean slope of 2.0, as compared to 97.4, 65.8 and 33.8 in not treated subjects, with a mean slope of 2.6 (slope difference: 0.6