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Pharmacological blockade of asct2-dependent glutamine transport leads to antitumor efficacy in preclinical models

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Interestingly, there is evidence for reduced striatal DA levels in both R6/2 and YAC128 mice at later disease stages concomitant with motor abnormalities 50,51,52

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this communication system between the enteric nervous system and the central nervous system includes the emotional and cognitive centers of the brain [151]