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The tumor blocks were arranged according to the group and photographed for records
MNA cells rely on an elevated antioxidant response through the Xc-/glutathione (GSH) pathway to scavenge lipid hydroperoxides, a by-product formed from excess H 2 O 2 ( We recently discovered in a drug screen that Diphenyleneiodonium chloride (DPI) selectively induces cell death of MNA NB cells in vitro and decreases tumor growth in vivo ( Although precision therapy for individual patients remains limited, combination therapy has the potential to enhance treatment efficacy while potentially reducing reliance on highly toxic chemotherapy ( 2 Results 2.1 MitoQ induces cell death and differentiation in neuroblastoma cells and potentiates DPI-induced cytotoxicity To investigate whether enhanced ROS production mediates the cytotoxic effects of DPI, we used MitoQ, a ROS scavenger that selectively accumulates in mitochondria ( Supplementary Figure S1 )
After reaction, surfactant is removed, and resulting NPs are washed and calcined to create MSNs (Gustafsson and Holmberg 2017
Molecules 26 (11), 3421
They've been extensively researched for their wound healing, anti-inflammatory, and antioxidant properties that lend to their potential skin regeneration, hair growth, and anti-aging benefits
