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Glucose uptake increases due to the upregulation of GLUT1, while the regulation of key enzymes like HK2 and PKM2 alters the flow of glycolytic products

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Several laboratory studies have reported that UA has pro-inflammatory properties, including triggering the Akt/PRAS40 pathway, inducing IL-1 release, promoting ROS generation, and activating the toll-like receptor (TLR) 2/4 and NF-B signaling [48, 49]