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This abnormality is of great concern as endocannabinoid compounds are needed for proper synaptogenesis (connections between brain cells), axon growth and positioning (size and where these brain cells are located), and neuronal cell fate (whether a neuron lives or dies in a process known as apoptosis)

Furthermore, the study noted an apparent reduction in myeloperoxidase (MPO) activity, which is primarily found in neutrophils and is an enzyme involved in the model's response to inflammation

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Abdominal pain, nausea, vomiting, diarrhea, and vertigo have also been reported, and one trial found that the incidence of nausea, vomiting, and vertigo was dose-dependent (77)