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Large-scale epidemiological surveys in Chinese commercial farms indicated that under conditions of high temperaturehumidity or organic bedding, milk frequently tested positive for pathogens such as Escherichia coli and Klebsiella spp., which ascended via the teat canal, thereby shifting the etiological profile toward environmental pathogens 132

Additionally, the crossover design improves statistical efficiency, as the variance between participants is reduced, allowing for a smaller sample size while maintaining the ability to detect significant effects

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