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In addition, astrocytes, which normally support neurons, become dysfunctional through a process called astrogliosis, which worsens glutamate imbalance and reduces neuronal support (Taylor et al., 2016), and genetic mutationssuch as SOD1 (causing harmful protein accumulation), FUS (interfering with RNA handling), and TBK1 or OPTN (which impair the cell's waste disposal system known as autophagy

They may refer to it as an investigational drug or one thats still undergoing clinical research. Those that do mention the lack of FDA approval tend to do so in tiny print at the bottom of a product page

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V., & Mueller, J