At the same time, oxidative stress, which is caused by mitochondrial damage, activation of NADPH oxidase, and other environmental or treatment-related insults, promotes tumourigenesis through a cascade of events including: oxidative DNA adducts (8-oxo-dG), lipid peroxidation (4-HNE), protein oxidation, redox-regulated oncogene activation and mutagenesis, inhibition of the DNA repair machinery, and a vicious cycle of genomic instability accompanied by inflammatory signalling (178180)
Biochemistry38, 13,78713,794
MZB were stimulated with 1ug/mL of LPS (Sigma L2630)
Antioxidant additive melatonin in tris-based egg yolk extender improves post-thaw sperm attributes in Hariana bull
Cell Death Differ 9(4):367393