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Measurements of metabolite-pairs to determine the redox state appear to be most important for studies determining the effects of fasting or DR on the mitochondrial [NAD + ]/[NADH], where measurements of mitochondrial total NAD + /NADH following fasting showed either no change or an oxidizing redox shift, opposite to the reducing redox shift indicated by measurements of the tissue acetoacetate/beta-hydroxybutyrate indicative of the mitochondrial (free) [NAD + ]/[NADH] (Nakagawa et al., 2009

In this study, our first aim was to investigate the relationship between oxidative stress and in refractory epilepsy

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