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Overexpression of MDM2 results in decreased level and activity of p53 (Kubbutat et al, 1997) and provides an alternative to a p53 mutation in the sense that it inactivates p53

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NAD(P)H autofluorescence The NADH/NADPH [NAD(P)H] levels of WT and Taz -KD pancreatic islets were measured in Clariostar plate reader experiments ( ex =340/10 nm, BS=410 nm, em =450/10 nm) in parallel to other parameters (mitochondrial membrane potential and H 2 O 2 )