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In contrast, the levels of cytokines involved in the control of melanocyte proliferation and differentiation and the inhibition of melanogenesis, IL-17, IL-4 and IL-6, were significantly increased in the vitiligo group compared with the control group
Moreover, the integration of emerging technologiessuch as CRISPR gene editing, metabolomics, and single-cell spatial analysisoffers new opportunities to elucidate the regulatory mechanisms of Vitamin D and its metabolic pathways, potentially extending their application from classical biochemical regulation to precision-level personalized interventions
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The critical role of the SLC46A1 encoded transporter in intestinal folate absorption is evident in individuals with an inherited form of folate malnutrition (hereditary folate malabsorption, HFM) that results from mutations in the SLC46A1 gene
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