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Leoni, G

Mannervik B, Awasthi YC, Board PG, Hayes JD, Di Ilio C, Ketterer B et al

At the molecular level, the mechanism has been structurally resolved by NMR spectroscopy (Nature Communications, 2025): FOXO4-DRI binds to the disordered p53 TAD2 domain and forms a transiently folded complex through both the FOXO4-derived peptide region and its cationic cell permeability element

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Similarly, elderly or frail patients, who may struggle with multiple visits or have difficulty implementing avoidance strategies, are often better suited to broad-acting therapeutic approaches rather than exhaustive diagnostic workups [42, 59]