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Rabbit models of osteoarthritis have been examined, with observations pointing to potential changes in joint mobility and cartilage condition

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Trends in Endocrinology & Metabolism 28(5):340-353

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What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug