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Furthermore, the inhibition of the TLR4/NF-B pathway, MAPK pathway, GSK-3 signaling pathway, miR-155-5p-mediated neuroinflammation, and ferroptosis could account for their protective effects

However, while CD4 -/- or Rag1 -/- knock-out mice injected with MPTP were partly protected from severe neurodegeneration (42), 6-OHDA-treated Rag1 -/- mice showed even more pronounced neurodegeneration in the SN than immune-competent mice (201) or rats (214)

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