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Cystine enters cells through Xc and is reduced to cysteine via the cystine reduction pathway dependent on GSH or thioredoxin reductase 1 (TXNRD1), thereby promoting GSH synthesis [78]

Additionally, it has been revealed that GTP cyclohydrolase 1 (GCH1), through its metabolites tetrahydrobiopterin (BH4) and dihydrobiopterin (BH2), is resistant to ferroptosis [41]

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Scotter, E