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Once depleted, cells lose their ability to neutralize reactive oxygen species, defend against ferroptosis, support proper iron metabolism, and maintain immune and neurological function

This minimal 2:1 c-MET:HGF active complex is further stabilized by the second HGF molecule and heparin, leading to a more stable 2:2 complex and enhanced activation of c-MET

Gentile, V., Antonini, G., Antonella, Bertozzi M., Dinelli, N., Rizzo, C., Ashraf, Virmani M., and Koverech, A

The reversible reduction of GSSR substrates usually requires only the first active-site cysteinyl residue and is therefore catalyzed by a monothiol mechanism with ping-pong bi-bi kinetic patterns (Fig

doi: 10.1080/10408398.2017.1360837 147