A special complex soothes, regenerates, and boosts the skin's natural defenses
In response to tissue damage, NFs can rapidly expand to produce more ECM-secreting fibroblasts that are critical to tissue synthesis, as well as myofibroblasts with high expression of contractile proteins such as -SMA [256]
These crystals can form as a result of defects in the absorption or metabolism of various natural substances such as uric acid (which produces gout) and calcium pyrophosphate (pseudogout)
As previously described in several models of inflammatory pain [21,22], our study demonstrated that cortistatin acts as an endogenous natural analgesic that is produced in response to nociceptive stimuli, including nerve injury, in parallel to nociceptive peptides to mitigate persistent painful sensitization
This is achieved through the formation of mitochondrial and endoplasmic reticulum contact sites (Oanh et al., 2017)