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SCFA binding to FFAR2/3 stimulates enteroendocrine cells to release peptide YY (PYY) and GLP-1, hormones that regulate appetite and energy intake through the gut-brain axis (81)

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Attack on DNA may trigger cell apoptosis or gene mutation, affect the normal proliferation and differentiation of thyroid cells, further damage the synthesis and secretion of thyroid hormone, and eventually aggravate the hypothyroidism condition (Lushchak, 2014)

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