Some GSTs are capable of mediating the conjugation of the available sulfhydryl group of reduced glutathione (GSH) to the electrophilic central carbon atom of the isothiocyanate group 27,28,29,30
Glutathione is a tripeptide composed of three amino acids: cysteine, glutamine, and glycine
Their diameter is between 3 m and 8 m, and they are a chemical and physical barrier to toxins, small organic drugs, ions, and macromolecules, protecting the brain from external damaging factors [3842]
Another randomized controlled trial showed that soybean isoflavone therapy (80 mg/day, P.O for 24 weeks) significantly increased the protein and mRNA levels of Nrf2 and the concentrations of SOD as well as diminished serum levels of inflammatory factors and MAD in patients with myocardial ischemia [139]
^ The pathobiology of diabetic complications: A unifying mechanism