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5.1.3 Retinoids All trans retinoic acid (ATRA), isotretinoin, retinol, retinaldehyde, tazarotene, and adapalene are among retinoids used as depigmenting agents in melasma management

Studies also show a 32% adverse event rate, including liver dysfunction

Together, these findings position NRF2 as the central mediator of melatonin-induced metabolic reprogramming and functional suppression in ILC2s and identify NRF2 as a therapeutically actionable target

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