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Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), is a chronic condition characterized by a range of persistent symptoms that last for weeks or months following the initial COVID-19 infection, affecting multiple organ systems and significantly impairing daily functioning and quality of life

A positive feedback loop between AMPK and GDF15 promotes metformin antidiabetic effects

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Future research must not only deepen our mechanistic understanding but also prioritize rigorous human studies to evaluate the safety and efficacy of lactate-targeted therapies

The kinase activity of PFK-2 converts fructose-6-phosphate into fructose-2,6-bisphosphate (F2,6BP)