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J Biol Chem 291: 95019512

It uses a methyl group donated by S-adenosylmethionine (SAM) to methylate nicotinamide a vitamin B3 form that would otherwise be recycled back into NAD+

A naturally occurring antioxidant involved in cellular protection and detox pathways

Neuroleptic Malignant Syndrome (NMS): A potentially fatal symptom complex may occur with administration of antipsychotic drugs, including ARISTADA INITIO and ARISTADA

For states of systemic inflammation that involve cells of the peripheral immune system, while for neurodegenerative and neuroinflammatory diseases such as AD, PD, and MS, penetration of the CNS is necessary (Lin et al., 2024