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By incorporating cells that retain the molecular and functional features of the native tissue, these platforms allow researchers to reproduce patient specific disease mechanisms and treatment responses in vitro

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Fujian Provincial Natural Science Foundation of China (2024Y0035)

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7.4 Clinical translation gaps Currently, there is a lack of studies demonstrating that periodontal/oral hygiene treatment can improve depressive symptoms, suggesting that the clinical translational potential of oral microecological interventions in mental health remains to be explored