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Measurement of the renal glutathione (GSH)/oxidized glutathione (GSSG) ratio and malondialdehyde (MDA) and superoxide dismutase (SOD) levels GSH and GSSG levels were measured by kits purchased from Beyotime (S0053, Shanghai, China), and MDA (thiobarbituric acid method) and SOD (hydroxylamine method) levels were measured by kits purchased from Jiancheng Bioengineering Institute (A003-1 and A001-1, Nanjing, China) in fresh mouse renal tissues according to the manufacturers instructions, as we described previously 29

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In other words, Cagrilintide is often treated as a second-step optimisation peptide , layered on top of a GLP-1 foundation rather than replacing it

OAA is then converted to malic acid, which in turn generates NADPH through ME1

Below 30% relative humidity, most lyophilized peptides maintain reasonable stability at room temperature