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[DOI] [PubMed] [Google Scholar] 63.Kawaguchi K, Han Q, Li S, Tan Y, Igarashi K, Kiyuna T, et al

Emerging nanotechnology approaches, including polymeric nanoparticles and lipid-based delivery systems, show promise in enhancing SFN stability, prolonging circulation time, and improving tumor-specific delivery (94, 102)

Small Klotho-derived peptides that maintain antifibrotic effects without metabolic imbalances have been proposed as an alternative [55]

The side effects that seem overwhelming in month 2 become distant memories by month 6

Such studies remind us that negative or nuanced outcomes are often the most enlightening, pushing the field forward and helping refine both scientific questions and clinical practice