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In OA models induced by interleukin-1 beta (IL-1) and ferric ammonium citrate (FAC), hallmark ferroptosis markers such as glutathione peroxidase 4 (GPX4) and solute carrier family seven member 11 (SLC7A11) exhibit significant downregulation, whereas expression levels of the tumor suppressor gene p53 and acyl-CoA synthetase long-chain family member 4 (ACSL4) are elevated (Yao et al., 2021)

doi.org/10.3389/fphar.2021.627533 Goldstein, A

22 A growing body of evidence indicates that extra virgin olive oil is rich in unsaturated fatty acids and phytochemicals could be used potentially for cardiovascular protection, cancer prevention, and anti-inflammatory properties

Antioxid Redox Signal (2013) 19:595637

Although oxidative stress is significantly increased in the presence of microvascular complications [19], it is not clear if patients with complications have more impaired glutathione metabolism compared to diabetic patients without complications