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H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)

*Correspondence: Luhua Lai, [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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