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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability

This is a rough guide and can be adjusted based on symptom severity and the severity of deficiency

The Institute of Medicine reports that no adverse effects have been associated with excess vitamin B12 intake from food and supplements in healthy individuals. However, if youre not deficient in vitamin B12 to begin with or you dont address the underlying reasons you might be deficient, i.e

Vitamin B12 deficiency can occur through insufficient diet (e.g., un-supplemented veganism or absorption issues (e.g., pernicious anaemia) Treatment for B12 deficiency is regular intramuscular injections until symptoms improve

Research suggests the opposite