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The reduction in AUC after oral administration can result from numerous mechanisms including: pH or bacterial-mediated metabolism of the drug within the GI tract, incomplete drug absorption from the GI tract, metabolism within the GI epithelium (which contains CYP3A4), excretion back into the GI tract by P-glycoprotein in the GI epithelium, hepatic metabolism, or biliary excretion into the GI tract

The one or more hepatocyte growth factor mimics have a general structural formula , -R 3 -R 3 -NH-(CH 2 ) ir C-NH 2 1 2 3 where i is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine

Round up for priming losses, dropped syringes, damaged swabs, and any protocol adjustments

Clin Invest Med Volume 1991;14:296-309

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