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Researchers also found CD patients possess a reduction in Roseburia spp., Clostridium and Bacteroides species, known to be producers of butyrate, which is fundamental to intestinal cell homeostasis and mucosal barrier integrity [137, 138]

Short-term nicotine use can enhance attention and alertness, but chronic use leads to neural adaptations and cognitive deficits

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Chemical and bacterial peritonitis due to peritoneal perforation is a surgical emergency that causes sudden and severe upper abdominal pain