The regulatory phenotype of FLS have potent inhibitory effects on T cells, but it is deficient in RA
Wnt/-catenin is also a potential therapeutic target for common but refractory diseases such as psoriasis, viral infections, and obesity
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doi: 10.2147/DDDT.S146521 4 KratzJM
This instability may result from inadequate demethylation of conserved non-coding sequence regions in the Foxp3 locus, known as the Treg-specific demethylation region (TSDR), which is fully demethylated in thymus-derived Tregs (tTregs) but often methylated in iTregs ( in vitro systems, and their physiological relevance, particularly in human disease, requires further validation