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Terrile et al., 2011), glyceraldehyde-3-phosphate dehydrogenase (GAPDH

FIGURE 5 The Effect of GSTP1 on AQ-QI- and DEAQ-QI-Induced Alteration on Cellular GSH Homeostasis To evaluate whether cellular GSH homeostasis was affected by QIs, and whether GSTP1 did influence the effects, concentrations of intracellular GSH and GSSG were quantified following exposure to synthetic AQ-QI and DEAQ-QI

( B ) Intracellular GSH:GSSG correlates with predicted FEV 1 % ( n = 26), while in small numbers the association with baseline exacerbations ( n = 15) is not significant

Liver histology demonstrates canalicular cholestasis and the absence of genuine ductular growth, with only periportal biliary metaplasia of hepatocytes