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Background Smoking tobacco is the world's leading cause of preventable illness and death (World Health Organization Reference Weinberger, Platt and Copeland2011)

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And so at the population level, what matters is patterns of actual use." The potential for heated tobacco products to reduce harm depends greatly on whether users transition entirely away from smoking or use them as only a partial substitute

2D,E) was hypersensitive to CS-TSB, suggesting a role of WTAs in mediating resistance to CS-TSB inhibition