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Although a specific cause has not yet been identified, certain factors can trigger or worsen melasma, including: Sun exposure The most common cause of melasma is direct sunlight

Tesamorelin is contraindicated in active malignancy

Environ Chem Lett 19(1):2542

Diabetes is a metabolic disorder that is characterized by a state of hyperglycemia, that occurs alongside dysregulations in insulin levels and in some cases, it arises concurrently to overweight and obesity (International Diabetes Federation, 2021)

We also performed the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) staining of tumors and hearts from the DOX and DOX/LAAM GSH-CQD groups