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Circulating plasma levels of pregnenolone, progesterone, estrogen, luteinizing hormone, and follicle stimulating hormone in young and aged C57BL/6 mice during various stages of pregnancy

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Issues such as poor bioavailability, rapid metabolism, and limited bloodbrain barrier permeability hinder the therapeutic application of polyphenols

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Its stimulant-free mechanism reduces the risk of anxiety or cardiovascular stress, making it suitable for a broader range of patient profiles , including those with type 2 diabetes or metabolic syndrome