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In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver
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AOD-9604 is a modified fragment of human growth hormone (specifically amino acids 176-191) that was developed to isolate the fat-reducing properties of growth hormone while eliminating the metabolic side effects
[10] Diabetes Obesity & Metabolism (2024) NNMT inhibition mitigates obesity-linked metabolic imbalance and liver pathology (translational perspective)
